Patent · US Active

Use of D-serine derivatives for the treatment of anxiety disorders

US8450336B2 · kind B2 · utility

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9Claims
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Key dates

Filing dateDec 14, 2007
Grant dateMay 28, 2013
Priority date—
Expiry dateApr 1, 2029

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC07C311/46
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

Compounds of Formula I are useful for the treatment of anxiety disorders such as generalized anxiety disorder (GAD), panic attack, post traumatic stress disorder (PTSD), obsessive compulsive disorder (OCD) and social phobias. wherein: A is chosen from: aryl or heteroaryl, A being optionally substituted with up to 5 independently-selected groups R8; R1 is chosen from: alkyl or haloalkyl; R2 is chosen from: H, C(O)R6, C(O)OR6, SO2R6 or C(O)NR6R7; R3, R4 and R5 are independently chosen from: H or alkyl; R6 and R7 are independently chosen from: H or alkyl; and R8 is chosen from: OH, CN, halo, alkyl, alkoxy, haloalkyl, haloalkoxy, C(O)R6, C(O)OR6, SO2R6 or C(O)NR6R7.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.