Method for inducing a multiclade immune response against HIV utilizing a multigene and multiclade immunogen

US8454972B2 · kind B2 · utility

Assignees

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US
• GenVec, Inc. · US

Inventors

• Gary J. Nabel · Cambridge, US
• Yue Huang · Bethesda, US
• Ling Xu · Potomac, US
• Bimal Chakrabarti · Gaithersburg, US
• Lan Wu · Bound Brook, US
• Zhi-yong Yang · Potomac, US
• Jason G. D. Gall · Germantown, US
• C. Richter King · Washington, US

Key dates

• Filing date: Jan 20, 2011
• Grant date: Jun 4, 2013
• Expiry date: Jan 20, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2740/16371
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure provides compositions for eliciting an immune response, including a prophylactic immune response, against human immunodeficiency virus. The composition includes nucleic acid constructs encoding HIV antigenic polypeptides of multiple clades or strains. Methods for eliciting an immune response by administering the composition to a subject are also provided.