miR 204, miR 211, their anti-miRs, and therapeutic uses of same

US8455454B2 · kind B2 · utility

Assignee

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US

Inventors

• Fei Wang · Beijing, CN
• Sheldon S. Miller · Berkeley, US
• Congxiao Zhang · Rockville, US
• Arvydas Maminishkis · Washington, US

Key dates

• Filing date: Aug 26, 2009
• Grant date: Jun 4, 2013
• Expiry date: Aug 26, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2310/141
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Embodiments of the invention provide methods of preventing or treating detrimental epithelial cell proliferation, loss of epithelial cell differentiation, age-related macular degeneration and/or proliferative vitreal retinopathy in an individual comprising administering to an individual in need thereof an effective amount of miR 204, an effective amount of miR 211, or an effective amount of a mixture of miR 204 and miR 211. A further embodiment of the invention provides a method of facilitating the transport of a substance across an epithelium in an individual comprising administrating to an individual an effective amount of anti-miR 204, an effective amount of anti-miR 211, or an effective amount of a mixture of anti-miR 204 and anti-miR 211. Additional embodiments of the invention include pharmaceutical compositions of miR 204 and/or miR 211 and pharmaceutical compositions of anti-miR 204 and/or anti-miR 211.