Method for selecting SIRNAs from a plurality of SIRNAs for gene silencing
US8457902B2 · kind B2 · utility
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1References
13Claims
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Key dates
| Filing date | May 4, 2011 |
| Grant date | Jun 4, 2013 |
| Priority date | — |
| Expiry date | May 4, 2031 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG16B20/00
- WIPO fieldComputer technology
- WIPO sectorElectrical engineering
Abstract
The present invention provides a method for identifying siRNA target motifs in a transcript using a position-specific score matrix approach. The invention also provides a method for identifying off-target genes of an siRNA using a position-specific score matrix approach. The invention further provides a method for designing siRNAs with higher silencing efficacy and specificity. The invention also provides a library of siRNAs comprising siRNAs with high silencing efficacy and specificity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.