Anti-vascular endothelial growth factor receptor-2 chimeric antigen receptors and use of same for the treatment of cancer

US8465743B2 · kind B2 · utility

Assignee

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US

Inventors

• Steven A. Rosenberg · Potomac, US
• Dhanalakshmi Chinnasamy · North Potomac, US

Key dates

• Filing date: Sep 14, 2010
• Grant date: Jun 18, 2013
• Expiry date: Sep 14, 2030

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N33/5091
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The invention provides chimeric antigen receptors (CARs) comprising an antigen binding domain of a KDR-1121 or DC101 antibody, an extracellular hinge domain, a T cell receptor transmembrane domain, and an intracellular domain T cell receptor signaling domain. Nucleic acids, recombinant expression vectors, host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical compositions relating to the CARs are disclosed. Methods of detecting the presence of cancer in a host and methods of treating or preventing cancer in a host are also disclosed.