Modulators of sphingosine phosphate receptors

US8466183B2 · kind B2 · utility

Assignee

• THE SCRIPPS RESEARCH INSTITUTE · US

Inventors

• Edward Roberts
• Hugh Rosen · Village of La Jolla, US
• Steven Brown · Village of La Jolla, US
• Miguel A. Guerrero · San Diego, US
• Xuemei Peng · Village of La Jolla, US
• Ramulu Poddutoori · Karimnagar, IN

Key dates

• Filing date: Sep 6, 2012
• Grant date: Jun 18, 2013
• Expiry date: Sep 6, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D401/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of the following generic structure are provided:Such compounds activate a sphingosine-I-phosphate receptor of the subtype 1 (S1P1), and have utility in the treatment of malconditions mediated by S1P1 activation. More specifically, such compounds are beneficial in the treatment of, for example, multiple sclerosis, transplant rejection and/or adult respiratory syndrome.