Isoindolinone inhibitors of phosphatidylinositol 3-kinase

US8466288B2 · kind B2 · utility

Assignee

• Vertex Pharmaceuticals Incorporated · US

Inventors

• Alex Aronov · Newton, US
• Jon Come · Cambridge, US
• Robert J. Davies · Arlington, US
• Albert Pierce · Cambridge, US
• Philip Collier · Arlington, US
• Ronald Grey, Jr. · Mansfield, US
• Hardwin O'Dowd · Boston, US
• James A. Henderson · Cambridge, US
• Elaine B. Krueger · Cambridge, US
• Arnaud Le Tiran · Chatou, FR
• Yusheng Liao · Lexington, US
• David Messersmith · Somerville, US
• Jian Wang · Newton, US
• Suganthini S. Nanthakumar · Newton, US
• Jingrong Cao · Newton, US
• Upul K. Bandarage · Lexington, US
• Anne-Laure Grillot · Cambridge, US

Key dates

• Filing date: Jan 13, 2012
• Grant date: Jun 18, 2013
• Expiry date: Jan 13, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D491/20
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3Kγ. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.