Methods of altering an immune response induced by CpG oligodeoxynucleotides
US8470342B2 · kind B2 · utility
5Cited by
0References
17Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 12, 2011 |
| Grant date | Jun 25, 2013 |
| Priority date | — |
| Expiry date | Aug 14, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2320/50
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
It is disclosed herein that agents that affect the activity and/or expression of CXCL16 can be used to alter the uptake of D-type CpG oligodeoxynucleotides (D ODNs). Methods of inducing an immune response are disclosed that include administering agents that increase the activity and/or expression of CXCL16 and a D ODN. Methods of decreasing an immune response to a CpG ODN are also disclosed. These methods include administering an agent that decreases the activity and/or expression of CXCL16. Compositions including one or more D-type ODNs and an agent that modulates that activity and/or expression of CXCL16 are provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.