N-[piperazinyl hetaryl]arylsufonamide compounds with affinity for the dopamine D3 receptor

US8476275B2 · kind B2 · utility

Assignee

• Abbott GmbH & Co. KG · DE

Inventors

• Wilfried Braje · Ludwigshafen, DE
• Andreas Haupt · Ludwigshafen, DE
• Wilfried Lubisch · Mannheim, DE
• Roland Grandel · Dossenheim, DE
• Karla Drescher · Ludwigshafen, DE
• Hervé Geneste · Schifferstadt, DE
• Liliane Unger · Ludwigshafen, DE
• Daryl Sauer · Pleasant Prairie, US
• Sean Colm Turner · Ludwigshafen, DE

Key dates

• Filing date: May 27, 2011
• Grant date: Jul 2, 2013
• Expiry date: May 27, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention related to N-[(piperazinyl)hetaryl]arylsulfonamide compounds of the general formula (I) in which Q is a bivalent, 6-membered heteroaromatic radical which possesses 1 or 2 N atoms as ring members and which optionally carries one or two substituents Ra which is/are selected, independently of each other, from halogen, CN, NO2, CO2R4, COR5, C1-C4-alkyl and C1-C4-haloalkyl; Ar is phenyl or a 6-membered heteroaromatic radical which possesses 1 or 2 N atoms as ring members and which optionally carries one or two substituents Rb, which is/are selected from halogen, NO2, CN, CO2R4, COR5, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C3-C6-cycloalkyl, C3-C6-cycloalkyl-C1-C4-alkyl and C1-C4-haloalkyl, with it also being possible for two radicals Rb which are bonded to adjacent C atoms of Ar to be together C3-C4-alkylene; R1 is hydrogen, C1-C4-alkyl, C1-C4-haloalkyl, C3-C6-cycloalkyl, C3-C6-cycloalkyl-C1-C4-alkyl, C1-C4-hydroxyalkyl, C1-C4-alkoxy-C1-C4-alkyl, C3-C4-alkenyl or C3-C4-alkynyl; with the radicals n, R1, R2, R3, R4 and R5 having the meanings given in the patent claims, to the N-oxides and to the physiologically tolerated acid addition salts of these compounds and to pharm…