Patent · US Active

Process for making modulators of cystic fibrosis transmembrane conductance regulator

US8476442B2 · kind B2 · utility

81Cited by

0References

13Claims

0Family size

Assignee

Vertex Pharmaceuticals Incorporated · US

Inventors

John DeMattei · San Diego, US
Adam Looker · Newton, US
Bobbianna Neubert-Langille · Sudbury, US
Martin Trudeau · Shannon, US
Stefanie Roeper · Medford, US
Michael P. Ryan · Brookline, US
Dahrika Milfred Lao Yap · Cambridge, US
Brian R. Krueger · Cambridge, US
Peter Diederik Jan Grootenhuis · San Diego, US
Fredrick Van Goor · San Diego, US
Martyn Botfield · Concord, US
Gregor Zlokarnik · Village of La Jolla, US

Key dates

Filing date	Mar 19, 2010
Grant date	Jul 2, 2013
Priority date	—
Expiry date	Mar 19, 2030

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY02P20/55
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The invention provides a process for the preparation of a compound of Formula 1,comprising coupling a carboxylic acid of Formula 2with an aniline of Formula 3in the presence of a coupling agent.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.