Heterocyclic inhibitors of c-Met and uses thereof

US8481538B2 · kind B2 · utility

Assignee

• Vertex Pharmaceuticals Incorporated · US

Inventors

• Alexander Aronov · Watertown, US
• Jon Come · Cambridge, US
• John J. Court · Littleton, US
• David Deininger · New Brunswick, US
• David J. Lauffer · Saline, US
• Pan Li · Lexington, US
• Kira McGinty · Schenectady, US
• Suganthini S. Nanthakumar · Newton, US
• Dean Stamos · Carlsbad, US
• Kirk Tanner · Westborough, US

Key dates

• Filing date: Sep 18, 2007
• Grant date: Jul 9, 2013
• Expiry date: Nov 24, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D513/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides compounds useful as inhibitors of c-Met tyrosine kinase. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various proliferative disorders.