Hydroxyl, keto, and glucuronide derivatives of 3-(4-(7H-pyrrolo[2,3-d] pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile

US8486902B2 · kind B2 · utility

Assignee

• Incyte Corporation · US

Inventors

• James D. Rodgers · Landenberg, US
• Adam Shilling · Wilmington, US
• Argyrios G. Arvanitis · Kennett Square, US
• Stacey Shepard · Wilmington, US
• Laurine G. Galya · Wilmington, US
• Mei Li · Newark, US
• Frank M. Nedza · Wilmington, US

Key dates

• Filing date: Oct 8, 2010
• Grant date: Jul 16, 2013
• Expiry date: Oct 24, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides hydroxyl, keto, and glucuronide derivatives of 3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile.