Patent · US Active

2-aminoimidazole beta-secretase inhibitors for the treatment of alzheimer's disease

US8492387B2 · kind B2 · utility

0Cited by

1References

11Claims

0Family size

Assignee

Merck Sharp & Dohme LLC · US

Inventors

Ivory D. Hills · Deerfield, US
Craig A. Coburn · Royersford, US
Samuel L. Graham · Schwenksville, US
Keith P. Moore · Doylestown, US
Philippe G. Nantermet · Lansdale, US
Hemaka A. Rajapakse · Wyncote, US
Shawn J. Stachel · Perkasie, US
Hong Zhu · Shanghai, CN

Key dates

Filing date	Feb 18, 2009
Grant date	Jul 23, 2013
Priority date	—
Expiry date	Feb 18, 2029

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D413/10
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The present invention is directed to 2-aminoimidazole compounds of formula (I)which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.