3-carboxypropyl-aminotetralin derivatives and related compounds as mu opioid receptor antagonists
US8492399B2 · kind B2 · utility
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4Claims
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Key dates
| Filing date | Oct 16, 2012 |
| Grant date | Jul 23, 2013 |
| Priority date | — |
| Expiry date | Oct 16, 2032 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T436/173845
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides 3-carboxypropyl-aminotetralin compounds of formula (I):wherein R1, R2, R3, R4, R5, and R6 are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are antagonists at the mu opioid receptor. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat conditions associated with mu opioid receptor activity, and processes and intermediates useful for preparing such compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.