Methods of identifying a modulator that inhibits the binding between Epstein-Barr virus induced receptor 2 and cholesterol derived ligands
US8497075B2 · kind B2 · utility
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Key dates
| Filing date | Jul 12, 2009 |
| Grant date | Jul 30, 2013 |
| Priority date | — |
| Expiry date | Jul 12, 2029 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/321
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention relates to modulators of the interaction between Epstein-Barr Virus induced receptor-2 (EBi2) and cholest-5-ene-3b,7b,25-triol (7,25-dihydroxycholesterol) (“7,25DHC”) and/or cholest-5-ene-3b, 7b-diol (7-hydroxycholesterol) (“7HC”). The modulator maybe a small chemical molecule, antibody or other therapeutic protein. Methods of medical treatment and methods of identifying modulators are also described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.