Chimeric oligomeric compounds for modulation of splicing
US8501703B2 · kind B2 · utility
87Cited by
9References
24Claims
0Family size
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Key dates
| Filing date | Aug 29, 2006 |
| Grant date | Aug 6, 2013 |
| Priority date | — |
| Expiry date | Aug 29, 2026 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2320/33
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Disclosed herein are compounds, compositions and methods for modulating splicing of a selected target mRNA. Further provided are uses of the disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders. Methods of enhancing cellular uptake, modulating tissue distribution and enhancing pharmacological activity of RNase H-independent antisense oligonucleotides are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.