Soluble guanylate cyclase activators

US8507512B2 · kind B2 · utility

Assignee

• Merck Sharp & Dohme LLC · US

Inventors

• Ronald Kim · Essen, DE
• Emma R. Parmee · Scotch Plains, US
• Christopher Joseph Sinz · Middletown, US
• Olga A. Ziouzina · Teaneck, US

Key dates

• Filing date: Feb 24, 2010
• Grant date: Aug 13, 2013
• Expiry date: May 17, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D401/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This inventions relates to compounds having the structure Formula Iand pharmaceutically acceptable salts thereof which are soluble guanylate cyclase activators. The compounds are useful for treatment or prevention of cardiovascular diseases, endothelial dysfunction, diastolic dysfunction, atherosclerosis, hypertension, pulmonary hypertension, angina pectoris, thromboses, restenosis, myocardial infarction, strokes, cardiac insufficiency, pulmonary hypertonia, erectile dysfunction, asthma bronchiale, chronic kidney insufficiency, diabetes, or cirrhosis of the liver.