Biodegradable intravitreal tyrosine kinase implants

US8512738B2 · kind B2 · utility

Assignee

• Allergan, Inc. · US

Inventors

• Jeffrey L. Edelman · Irvine, US
• Patrick M. Hughes · Aliso Viejo, US
• Thomas C. Malone · Irvine, US
• Gerald W. De Vries · Laguna Hills, US
• Joan-En Chang-Lin · Tustin, US
• Jane-Guo Shiah · Irvine, US
• Thierry Nivaggioli · San Francisco, US
• Lon T. Spada · Walnut, US
• Wendy M. Blanda · Tustin, US

Key dates

• Filing date: Apr 29, 2005
• Grant date: Aug 20, 2013
• Expiry date: Sep 2, 2029

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P27/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Biocompatible intraocular implants include a tyrosine kinase inhibitor and a biodegradable polymer that is effective to facilitate release of the tyrosine kinase inhibitor into the vitreous of an eye for an extended period of time. The therapeutic agents of the implants may be associated with a biodegradable polymer matrix, such as a matrix that is substantially free of a polyvinyl alcohol. The implants can be placed in an eye to treat or reduce the occurrence of one or more ocular conditions, such as posterior ocular conditions.