Arylethynyl derivatives

US8513273B2 · kind B2 · utility

Assignee

• Hoffmann-La Roche Inc. · US

Inventors

• Luke Green · Basel, CH
• Wolfgang Guba · Memmingen, DE
• Georg Jaeschke · Basel, CH
• Synese Jolidon · Blauen, CH
• Lothar Lindemann · Basel, CH
• Antonio Ricci · Birsfelden, CH
• Daniel Rueher · Brochritti, FR
• Heinz Stadler · Basel, CH
• Eric Vieira · Frenkendorf, CH

Key dates

• Filing date: Feb 28, 2013
• Grant date: Aug 20, 2013
• Expiry date: Feb 28, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D498/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to ethynyl compounds of formula IwhereinR1, R2, R2′, R3, R3′, R4, R4′, U, V, W, Y, m, and n are as defined herein and to a pharmaceutically acceptable acid addition salts, to a racemic mixtures, or to its corresponding enantiomers and/or optical isomers and/or stereoisomers thereof. Compounds of formula I are allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5).