Process and intermediates for the synthesis of 1,2-substituted 3,4-dioxo-1-cyclobutene compounds

US8519168B2 · kind B2 · utility

Assignee

• Merck Sharp & Dohme LLC · US

Inventors

• Xiaoyong Fu · Edison, US
• Frank Bruno Guenter · Thalwil, CH
• Agnes S. Kim-Meade · Fanwood, US
• Kenneth Stanley Matthews · Stockton, US
• Mathew Maust · Westfield, US
• Timothy L. McAllister · Westfield, US
• Gerald Werne · Ketsch, DE
• Jason L. Winters · Plainsboro, US
• Jianguo Yin · Plainsboro, US
• Shuyi Zhang · Parsippany, US

Key dates

• Filing date: Jul 1, 2008
• Grant date: Aug 27, 2013
• Expiry date: Feb 7, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C237/44
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This application discloses a novel process for the preparation of 1,2-substituted 3,4-dioxo-1-cyclobutene compounds, which have utility, for example, in the treatment of CXC chemokine-mediated diseases, and intermediates useful in the synthesis thereof.