High potency siRNAS for reducing the expression of target genes
US8524680B2 · kind B2 · utility
10Cited by
293References
18Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 31, 2009 |
| Grant date | Sep 3, 2013 |
| Priority date | — |
| Expiry date | Feb 15, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2320/50
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention provides improved methods of attenuating gene expression through the phenomenon of RNA interference. The invention provides methods of synthesis of double stranded RNAs (dsRNAs) of increased potency for use as small interfering RNA (siRNA). Surprisingly and unexpectedly, siRNAs made by the methods of the invention are significantly more potent than previously available siRNAs.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.