Substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase

US8524728B2 · kind B2 · utility

Assignee

• Janssen Pharmaceutica NA · BE

Inventors

• Marc Gustaaf Celine Verdonck · Lille, BE
• Patrick René Angibaud · Louviers, FR
• Bruno Roux · Val-de-Reuil, FR
• Isabelle Noëlle Constance Pilatte · Louviers, FR
• Peter Ten Holte · Beerse, BE
• Janine Arts · Breda, NL
• Kristof Van Emelen · Sint-Niklaas, BE

Key dates

• Filing date: Feb 15, 2011
• Grant date: Sep 3, 2013
• Expiry date: Oct 13, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D491/056
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention comprises the novel compounds of formula (I)wherein R1, R2, R3, X and Y have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.