Tetrahydrothiazolopyridine inhibitors of phosphatidylinositol 3-kinase

US8524906B2 · kind B2 · utility

Assignee

• Vertex Pharmaceuticals Incorporated · US

Inventors

• Alex Aronov · Newton, US
• Upul K. Bandarage · Lexington, US
• Kevin Michael Cottrell · Cambridge, US
• Robert J. Davies · Arlington, US
• Elaine B. Krueger · Cambridge, US
• Mark Ledeboer · Acton, US
• Brian Ledford · Attleboro, US
• Arnaud Le Tiran · Chatou, FR
• David Messersmith · Somerville, US
• Tiansheng Wang · Concord, US
• Jinwang Xu · Framingham, US
• Yusheng Liao · Lexington, US

Key dates

• Filing date: Aug 17, 2011
• Grant date: Sep 3, 2013
• Expiry date: Aug 17, 2031

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3Kγ. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.