Pyridyl derivatives as CFTR modulators

US8524910B2 · kind B2 · utility

Assignee

• Vertex Pharmaceuticals Incorporated · US

Inventors

• Sara S. Hadida Ruah · Village of La Jolla, US
• Mark Miller · San Diego, US
• Jinglan Zhou · San Diego, US
• Brian Bear · Oceanside, US
• Peter Diederik Jan Grootenhuis · San Diego, US

Key dates

• Filing date: Jun 26, 2012
• Grant date: Sep 3, 2013
• Expiry date: Jun 26, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to modulators of Formula I and the accompanying definitions herein of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases such as cystic fibrosis using such modulators.