3-arylamino pyridine derivatives

US8524911B2 · kind B2 · utility

Assignee

• MERCK SERONO SA · CH

Inventors

• Ulrich Abel · Schifferstadt, DE
• Holger Deppe · Heidelberg, DE
• Achim Feurer · Wilhelmsfeld, DE
• Ulrich Grädler · Heidelberg, DE
• Kerstin Otte · Heidelberg, DE
• Renate Sekul · Ladenburg, DE
• Meinolf Thiemann · Schriesheim, DE
• Andreas Goutopoulos · Boston, US
• Matthias Schwarz · Gland, CH
• Xuliang Jiang · Braintree, US

Key dates

• Filing date: May 16, 2012
• Grant date: Sep 3, 2013
• Expiry date: May 16, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D401/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides novel, substituted 3-arylamino pyridine compoundspharmaceutically acceptable salts, solvates and prodrug compounds thereof, wherein W, R1, R2, R9, R10, R11, R12, R13, R14 are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer, restenosis and inflammation. Also disclosed is the use of such compounds in the treatment of hyperproliferative diseases in mammals, especially humans, and pharmaceutical compositions containing such compounds.