Genetic markers associated with interferon-alpha response

US8535887B2 · kind B2 · utility

Assignee

• Merck Sharp & Dohme LLC · US

Inventors

• Arthur Bertelsen · Ridgewood, US
• Jacques Fellay · Durham, US
• Dongliang Ge · Raleigh, US
• David B. Goldstein · Durham, US
• John G. McHutchison · Chapel Hill, US
• Ping Qiu · Cranbury, US
• Kevin Shianna · Durham, US
• Jason Simon · Woodcliff Lake, US
• Alexander J. Thompson · Montville, US
• Thomas Urban · Durham, US

Key dates

• Filing date: May 21, 2010
• Grant date: Sep 17, 2013
• Expiry date: Oct 21, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2600/172
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides genetic markers on human chromosome 19 that are associated with a beneficial response to interferon alpha (IFN-α). These IFN-α response markers are useful, inter alia, to identify patients who are most likely to benefit from treatment with IFN-α pharmaceutical compositions and drug products, in methods of treating patients having a disease susceptible to treatment with an IFN-α, and in methods for selecting the most appropriate therapy for such patients.