AKT phosphorylation at Ser473 as an indicator for taxane-based chemotherapy

US8546091B2 · kind B2 · utility

Assignee

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US

Inventors

• Sherry X. Yang · Ellicott City, US
• Sandra SWAIN · Stevenage, GB

Key dates

• Filing date: May 21, 2010
• Grant date: Oct 1, 2013
• Expiry date: May 21, 2030

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2800/52
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Methods for determining whether a cancer patient is likely to benefit from treatment with a taxane compound based on Akt-Ser473 phosphorylation status are provided, together with kits for determining Akt-Ser473 phosphorylation status and methods for improving treatment of a cancer patient that include obtaining a determination of the Akt-Ser473 phosphorylation status of the cancer.