Sulfonyl-derivatives as novel inhibitors of histone deacetylase

US8557825B2 · kind B2 · utility

Assignee

• Janssen Pharmaceutica NA · BE

Inventors

• Kristof Van Emelen · Sint-Niklaas, BE
• Janine Arts · Breda, NL
• Leo Jacobus Jozef Backx · Arendonk, BE
• Hans Louis Jos De Winter · Schilde, BE
• Sven Franciscus Anna Van Brandt · Nijlen, BE
• Marc Gustaaf Celine Verdonck · Lille, BE
• Lieven Meerpoel · Beerse, BE
• Isabelle Noëlle Constance Pilatte · Louviers, FR
• Virginie Sophie Poncelet · Rodez, FR
• Alexey Borisovich Dyatkin · Masontown, US
• Jimmy Arnold Viviane Van heusden · Oelegem, BE

Key dates

• Filing date: Dec 14, 2011
• Grant date: Oct 15, 2013
• Expiry date: Dec 14, 2031

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2333/91
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention comprises the novel compounds of formula (I)wherein n, m, t, R1, R2, R3, R4, L, Q, X, Y, Z andhave defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.