Method for analyzing collagenous tissues for the detection and diagnosis of bone disease

US8568692B2 · kind B2 · utility

Assignee

• THE REGENTS OF THE UNIVERSITY OF MICHIGAN · US

Inventors

• Mark Banaszak-Holl · Ann Arbor, US
• Joseph Wallace · Indianapolis, US
• Blake Erickson · Gilroy, US
• Clifford M. Les · Birmingham, US
• Bradford G. Orr · Ann Arbor, US

Key dates

• Filing date: Jul 30, 2010
• Grant date: Oct 29, 2013
• Expiry date: Aug 22, 2031

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2800/10
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Methods and systems for diagnosing a bone disease related to collagen pathology in a subject are provided. These include providing a bone sample from the subject and determining a quantitative collagen morphology value of the bone sample. A reference value is provided from a non-affected control subject where the reference value is a quantitative collagen morphology value from the same type of bone sample obtained from a population of non-affected control subjects. The quantitative collagen morphology value of the subject's bone sample is compared to the reference value. If the collagen morphology value is altered versus the reference value, the subject is diagnosed as having a collagen related bone disease. The collagen morphology value can include mean fibril spacings and distributions of the fibril spacings taken from a subject's bone sample.