Compositions and methods for diagnosis and treatment of tumors
US8568977B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jul 16, 2012 |
| Grant date | Oct 29, 2013 |
| Priority date | — |
| Expiry date | Jul 16, 2032 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/52
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Based on the observation of the cooperation of osteopontin (OPN) and matrixmetalloproteinase-9 (MMP-9) in the promotion of the metastatic phenotype, therapies and diagnostic assays are disclosed for the treatment of a tumor that overexpresses OPN, such as hepatocellular carcinoma (HCC), for example metastatic HCC. In one example, methods of treating a tumor include administration of an agent that reduces cellular invasion resulting from the interaction between a fragment of OPN (OPN-5kD) generated by MMP-9 cleavage and CD44 receptor. Examples of such agents include fragments of OPN-5kD and antibodies specific for OPN-5kD. Therapeutic compositions are also provided that include such agents. Also provided are methods of diagnosing or prognosing a tumor, for example by detecting expression of OPN-5kD peptide or OPN-c mRNA in a biological sample obtained from the subject. Also provided are antibodies that specifically bind OPN-5kD.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.