Pentafluorosulfur imino heterocyclic compounds as BACE-1 inhibitors, compositions and their use
US8569310B2 · kind B2 · utility
9Cited by
5References
16Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 6, 2010 |
| Grant date | Oct 29, 2013 |
| Priority date | — |
| Expiry date | Oct 6, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D405/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
In its many embodiments, the present invention provides certain pentafluorosulfur imino heterocyclic compounds, including compounds Formula (a) and pharmaceutically acceptable salts thereof. Compounds of Formula (a) have the general structure: (a) wherein each variable is selected independently and as defined herein. Pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other active agents), and methods for their preparation and use in treating pathologies associated with amyloid beta (Aβ) protein, including Alzheimers Disease, are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.