Patent · US Active

Dual-acting benzyl triazole antihypertensive agents having angiotensin II type receptor antagonist activity and neprilysin-inhibition activity

US8569351B2 · kind B2 · utility

2Cited by

34References

3Claims

0Family size

Assignee

Theravance, Inc. · US

Inventors

Paul Allegretti · Fort Collins, US
Seok-Ki Choi · Ann Arbor, US
Roland Gendron · San Francisco, US
Paul R. Fatheree · San Francisco, US
Keith Jendza · Boston, US
Robert Murray McKinnell · Millbrae, US
Darren McMurtrie · Daly City, US
Brooke Olson · Williamstown, US

Key dates

Filing date	Dec 3, 2012
Grant date	Oct 29, 2013
Priority date	—
Expiry date	Dec 3, 2032

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D513/14
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The invention is directed to compounds having the formula:wherein: Ar, X, R3, and R5-7 are as defined in the specification, and pharmaceutically acceptable salts thereof. These compounds have AT1 receptor antagonist activity and neprilysin inhibition activity. The invention is also directed to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.