Pyrrolo[2,3-D]pyrimidines as inhibitors of Janus kinases

US8580802B2 · kind B2 · utility

Assignee

• Vertex Pharmaceuticals Incorporated · US

Inventors

• Francesco G. Salituro · Marlborough, US
• Luc Farmer · Foxborough, US
• Tiansheng Wang · Concord, US
• Jian Wang · Newton, US
• Randy S. Bethiel · Bedford, US
• Marion W. Wannamaker · Sharonville, US
• Gabriel Martinez-Botella · Wayland, US
• John P. Duffy · Westborough, US
• Alexander Aronov · Watertown, US
• David J. Lauffer · Saline, US
• Albert Pierce · Cambridge, US

Key dates

• Filing date: Sep 28, 2006
• Grant date: Nov 12, 2013
• Expiry date: Jan 30, 2029

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to compounds of the following structural formula:which are useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.