Ethynyl compounds useful for treatment of CNS disorders
US8586581B2 · kind B2 · utility
1Cited by
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8Claims
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Key dates
| Filing date | Dec 10, 2010 |
| Grant date | Nov 19, 2013 |
| Priority date | — |
| Expiry date | Dec 23, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D471/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to ethynyl compounds of formulawherein X, Y, Z, and R4 are as defined hereinor to a pharmaceutically acceptable salt or acid addition salt, to a racemic mixture, or to its corresponding enantiomer and/or optical isomer and/or stereoisomer thereof. Compounds of formula I are positive allosteric modulators (PAM) of the metabotropic glutamate receptor subtype 5 (mGluR5) and they are therefore useful for the treatment of diseases related to this receptor.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.