Therapeutic compounds

US8591878B2 · kind B2 · utility

Assignees

• Merck Sharp & Dohme LLC · US
• Istituto di Recerche di Biologia Molecolare P. Angeletti S.R.L. · IT

Inventors

• John A. McCauley · Maple Glen, US
• Nigel J. Liverton · Harleysville, US
• Steven Harper · Roma, IT
• Charles J. McIntyre · Lansdale, US
• Michael T. Rudd · Collegeville, US

Key dates

• Filing date: Feb 12, 2009
• Grant date: Nov 26, 2013
• Expiry date: Jan 17, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K5/0808
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A class of macrocyclic compounds of formula (I), wherein R1, R3, R4, Ra, Rb, A, B, Z, M, W and n are defined herein, that are useful as inhibitors of viral proteases, particularly the hepatitis C virus (HCV) NS3 protease, are provided. Also provided are processes for the synthesis and use of such macrocyclic compounds for treating or preventing HCV infection.