Tetrahydro-quinoline derivatives

US8592594B2 · kind B2 · utility

Assignee

• Hoffmann-La Roche Inc. · US

Inventors

• Li Chen · Shanghai, CN
• Lichun Feng · Shanghai, CN
• Yun He · San Diego, US
• Mengwei Huang · Shanghai, CN
• Yongfu Liu · Shanghai, CN
• Hongying Yun · Shanghai, CN
• Mingwei Zhou · Shanghai, CN

Key dates

• Filing date: Jun 27, 2011
• Grant date: Nov 26, 2013
• Expiry date: Dec 14, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A compound of formula (I)or a pharmaceutically acceptable salt or ester thereof, wherein A1 to A3 and R1 to R10 have the significance given in claim 1, can be used as a medicament. These compounds are useful in the treatment or prophylaxis of diseases that are related to AMPK regulation, such as obesity, dyslipidemia, hyperglycemia, type 1 or type 2 diabetes and cancers.