Imidazole derivatives and their use as modulators of cyclin dependent kinases
US8598217B2 · kind B2 · utility
Assignees
Inventors
- Steven Howard
- Paul Mortenson
- Steven Douglas Hiscock
- Alison Jo-Anne Woolford
- Andrew James Woodhead
- Gianni Chessari
- Marc O'Reilly
- Miles Stuart Congreve
- Claudio Dagostin
- Young Shin Cho
- Fan Yang
- Christine Hiu-Tung Chen
- Christopher Thomas Brain
- Bharat Lagu
- Yaping Wang
- Sunkyu Kim
- John William Giraldes
- Michael Joseph Luzzio
- Lawrence Blas Perez
Key dates
| Filing date | Apr 30, 2010 |
| Grant date | Dec 3, 2013 |
| Priority date | — |
| Expiry date | Sep 9, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D519/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention provides compounds of the formula (I):and salts, tautomers, solvates and N-oxides thereof;wherein Q is CH or N; X is N, N+—O− or CR3; Y is N, N+—O− or CR3a; R1 and R2 are independently selected from hydrogen and various substituents as defined in the claims; or R1 and R2 together with the atoms to which they are attached, link to form an optionally substituted carbocyclic or heterocyclic aromatic or non-aromatic ring of 4 to 7 members; R3 is selected from hydrogen and various substituents; and R3a is selected from hydrogen and various substituents as defined in the claims. Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds. The compounds of formula (I) have activity as inhibitors of CDK kinases and are useful in the treatment of inter alia proliferative diseases such as cancers.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.