Reverse amide compounds as protein deacetylase inhibitors and methods of use thereof

US8609678B2 · kind B2 · utility

Assignee

• Acetylon Pharmaceuticals, Inc. · US

Inventors

• John H. van Duzer · Phillipsburg, US
• Ralph Mazitschek · Belmont, US
• Walter Ogier · Winchester, US
• James E. Bradner · Weston, US
• Guoxiang Huang · Greensboro, US
• Dejian Xie · Shanghai, CN
• Nan Yu · Shanghai, CN

Key dates

• Filing date: Apr 2, 2012
• Grant date: Dec 17, 2013
• Expiry date: Apr 2, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to “reverse amide” compounds comprising a zinc chelator group, and the use of such compounds in the inhibition of HDAC6 and in the treatment of various diseases, disorders or conditions related to HDAC6.