Cellular and viral inactivation

US8613934B2 · kind B2 · utility

Assignee

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US

Inventors

• Yossef Raviv · Rockville, US
• Julie M. Belanger · Frederick, US
• Mathias D. Viard · Frederick, US
• Robert Blumenthal · Bethesda, US
• Julian W. Bess, Jr. · Frederick, US

Key dates

• Filing date: Jul 30, 2010
• Grant date: Dec 24, 2013
• Expiry date: Jan 4, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2760/16163
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention involves inactivation of viral populations by treating the viral populations with a compound to crosslink proteins in the viral membrane, UV irradiation and further inactivation of the viruses using detergent(s). According to the invention, this method preserves the native structure of viral epitopes so that the inactivated viral preparations can be used in immunological compositions that will inhibit and/or prevent viral infection when administered to an animal.