RAF kinase modulator compounds and methods of use thereof

US8618289B2 · kind B2 · utility

Assignee

• AMBIT BIOSCIENCES CORP. · US

Inventors

• Sunny Abraham · San Diego, US
• Shripad S. Bhagwat · San Diego, US
• Brian T. Campbell · Souderton, US
• Qi Chao · San Diego, US
• Raffaella Faraoni · San Diego, US
• Mark W. Holladay · San Diego, US
• Andiliy G. Lai · San Diego, US
• Martin Rowbottom · San Diego, US
• Eduardo Setti · San Diego, US
• Kelly G. Sprankle · Vista, US

Key dates

• Filing date: Mar 17, 2009
• Grant date: Dec 31, 2013
• Expiry date: May 4, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds according to formula (I), compositions and methods are provided for modulating the activity of RAF kinases, including BRAF kinase and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder mediated by RAF kinases. Formula (I): or a pharmaceutically acceptable salt, solvate, clathrate of hydrate thereof, wherein X is O or S(O)t; Ra is O or S.