Patent · US Active

Pyrrolidine derivatives

US8618303B2 · kind B2 · utility

2Cited by

1References

17Claims

0Family size

Assignee

Hoffmann-La Roche Inc. · US

Inventors

Henner Knust · Rheinfelden (Baden), DE
Matthias Nettekoven · Weil am Rhein, DE
Hasane Ratni · Habsheim, FR
Walter Vifian · Gelterkinden, CH

Key dates

Filing date	Jan 2, 2012
Grant date	Dec 31, 2013
Priority date	—
Expiry date	Jan 2, 2032

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D413/10
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The invention provides compounds of formulawherein R1, R2, R3, R4, R5, and R6 are as defined hereinor a pharmaceutically suitable acid addition salt thereof. The present compounds are high potential NK-3 receptor antagonists useful for the treatment of depression, pain, psychosis, Parkinson's disease, schizophrenia, anxiety and attention deficit hyperactivity disorder (ADHD).

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.