Recombinant protein carrying human papillomavirus epitopes inserted in an adenylate cyclase protein or fragment thereof therapeutic uses thereof

US8637039B2 · kind B2 · utility

Assignees

• INSTITUT PASTEUR · FR
• Institut National de la Sante et de la Recherche Medicale (INSERM) · FR
• CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE · FR
• GENTICEL · FR

Inventors

• Xavier Preville · Roquefort-les-Pins, FR
• Claude Leclerc · Paris, FR
• Daniel Ladant · Cachan, FR
• Benedikt Timmerman · Toulouse, FR

Key dates

• Filing date: Dec 23, 2010
• Grant date: Jan 28, 2014
• Expiry date: Jun 30, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2710/20022
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to a recombinant protein comprising one or several polypeptides bearing one or several epitopes of one or several HPV antigens, said polypeptides being inserted in the same or different permissive sites of an adenylate cyclase (CyaA) protein or of a fragment thereof, wherein said CyaA fragment retains the property of said adenylate cyclase protein to target Antigen Presenting Cells. It also concerns polynucleotides encoding the same. The recombinant protein or the polynucleotide can be used for the design of therapeutic means against HPV infection or against its malignant effects.