Patent · US Active

Antibodies with modified isoelectric points

US8637641B2 · kind B2 · utility

124Cited by

88References

6Claims

0Family size

Assignee

Xencor, Inc. · US

Inventors

Bassil Dahiyat · Altadena, US
Gregory Alan Lazar · Los Angeles, US
Matthew Bernett · Monrovia, US

Key dates

Filing date	Jul 29, 2011
Grant date	Jan 28, 2014
Priority date	—
Expiry date	Jul 29, 2031

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2317/94
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The invention relates generally to compositions and methods for altering the isoelectric point of an antibody, and in some cases, resulting in improved plasma pharmacokinetics, e.g. increased serum half-life in vivo.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.