Annellated 4-(indazolyl)-1,4-dihydropyridine derivatives and methods of use thereof

US8642595B2 · kind B2 · utility

Assignee

• Bayer Intellectual Property GmbH · DE

Inventors

• Martin Michels
• Markus Follmann
• Alexandros Vakalopoulos · Hilden, DE
• Katja Zimmermann · Mülheim an der Ruhr, DE
• Nicole Teusch · Uerdingen, DE
• Karen Engel · Waldkraiburg, DE

Key dates

• Filing date: May 29, 2009
• Grant date: Feb 4, 2014
• Expiry date: Jan 3, 2030

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention relates to novel annellated 4-(indazolyl)-1,4-dihydropyridine derivatives having protein tyrosine kinase inhibitory activity, to a process for the manufacture thereof and to the use thereof for the treatment of c-Met-mediated diseases or c-Met-mediated conditions, particularly cancer and other proliferative disorders.