Ethynyl nitrogen containing heteroaryl pyrazolidin-3-one derivatives
US8648088B2 · kind B2 · utility
3Cited by
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13Claims
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Key dates
| Filing date | Apr 24, 2012 |
| Grant date | Feb 11, 2014 |
| Priority date | — |
| Expiry date | Apr 24, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D487/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to ethynyl derivatives of formula Iwherein G, X, R1, R2, R3, R3′, R4, and R4′ are as defined hereinor to a pharmaceutically acceptable acid addition salt, to a racemic mixture, or to its corresponding enantiomer and/or optical isomer and/or stereoisomer thereof. Compounds of formula I are positive allosteric modulators (PAM) of the metabotropic glutamate receptor subtype 5 (mGluR5).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.