Tissue graft with non-aligned fiber matrix retains mesenchymal progenitor cells on the non-injury-facing side

US8652458B2 · kind B2 · utility

Assignees

• The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. · US
• The United States of America, as represented by the Secretary of the Army, U.S.A. · US
• The United States of America as Represented by the Secretary of the Department of Health and Human Services · US

Inventors

• Wesley M. Jackson · Albany, US
• Leon J. Nesti · Silver Spring, US
• Rocky S. Tuan · Pittsburgh, US

Key dates

• Filing date: Aug 5, 2009
• Grant date: Feb 18, 2014
• Expiry date: Aug 5, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2533/40
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A graft containing a scaffold that includes a matrix in which are positioned mesenchymal progenitor cells (MPCs) has the capacity to substantially improve wound healing, including wounds resulting from injury to nerve, bone and vascular tissue. MPCs can be harvested from debrided muscle tissue following orthopaedic trauma. The traumatized muscle-derived progenitor cells are a readily available autologous cell source that can be utilized to effect or improve wound healing in a variety of therapeutic settings and vehicles.