Inhibitors of the renal outer medullary potassium channel

US8673920B2 · kind B2 · utility

Assignee

• Merck Sharp & Dohme LLC · US

Inventors

• Alexander Pasternak · Brookline, US
• Aurash Shahripour · Rahway, US
• Haifeng Tang · South San Francisco, US
• Nardos Teumelsan · Linden, US
• Lihu Yang · Edison, US
• Yuping Zhu · Edison, US
• Shawn P. Walsh · Bound Brook, US

Key dates

• Filing date: Apr 27, 2010
• Grant date: Mar 18, 2014
• Expiry date: Feb 7, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D493/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention relates to compounds having structural Formula I:and pharmaceutically acceptable salts thereof which are inhibitors of the Renal Outer Medullary Potassium (ROMK) channel (Kir1.1). The compounds of Formula I are useful as diuretics and natriuretics and therefore are useful for the therapy and prophylaxis of disorders resulting from excessive salt and water retention, including cardiovascular diseases such as hypertension and chronic and acute heart failure.