Patent · US Active

Solid forms of N-[2,4-bis(1,1-dimethylethy)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide

US8674108B2 · kind B2 · utility

70Cited by

27References

28Claims

0Family size

Assignee

Vertex Pharmaceuticals Incorporated · US

Inventors

Brian Luisi · Somerville, US
Sneha G. Arekar · Watertown, US
Adriana Costache · Cambridge, US
Kirk Dinehart · Holliston, US
Steven C. Johnston · Litchfield, US
Bobbianna Neubert-Langille · Sudbury, US

Key dates

Filing date	Apr 20, 2012
Grant date	Mar 18, 2014
Priority date	—
Expiry date	Apr 20, 2032

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61P37/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention relates to crystalline solvate forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1) and methods for their preparation. The present invention further relates to pharmaceutical compositions comprising the crystalline solvate forms, as well as methods of treatment therewith.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.