Raf modulators and methods of use
US8697737B2 · kind B2 · utility
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18Claims
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Assignee
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Key dates
| Filing date | Oct 12, 2010 |
| Grant date | Apr 15, 2014 |
| Priority date | — |
| Expiry date | May 1, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D413/14
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to compounds of the Formula I, wherein G, A, X1, X2, X3, Z, E, Y, and X are defined herein. The compounds modulate protein kinase enzymatic activity to modulate cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly Raf. Methods of using and preparing the compounds, and pharmaceutical compositions thereof, to treat kinase-dependent diseases and conditions are also an aspect of the invention.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.