Bridged piperidine derivatives

US8703763B2 · kind B2 · utility

Assignee

• Hoffmann-La Roche Inc. · US

Inventors

• Karlheinz Baumann · Weil am Rhein, DE
• Luke Green · Basel, CH
• Anja Limberg · Penzberg, DE
• Thomas Luebbers · Soest, DE
• Andrew Thomas · Birsfelden, CH

Key dates

• Filing date: Feb 27, 2012
• Grant date: Apr 22, 2014
• Expiry date: May 20, 2032

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P25/28
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to compounds of formula Ihetaryl I, hetaryl II, R1, R2, R3, Y,m, and o or to pharmaceutically active acid addition salts thereof. The present compounds of formula I are modulators for amyloid beta and thus, they may be useful for the treatment or prevention of a disease associated with the deposition of β-amyloid in the brain, in particular Alzheimer's disease, and other diseases such as cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-infarct dementia, dementia pugilistica and Down syndrome.